|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
Somatomedin C
Mechano growth factor
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Laron_syndrome
gptkb:diabetes_mellitus
acromegaly
growth hormone insensitivity
|
|
gptkbp:encodes
|
Insulin-like growth factor 1 protein
|
|
gptkbp:Entrez_Gene_ID
|
3479
ENSG00000017427
GC12M102559
|
|
gptkbp:expressedIn
|
gptkb:bone
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
collagen
adipose tissue
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_1
|
|
gptkbp:function
|
regulates cell growth and development
stimulates systemic body growth
mediates many of the growth-promoting effects of growth hormone
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:5464
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF1
|
|
gptkbp:length
|
70 amino acids
|
|
gptkbp:locatedOnChromosome
|
12
12q23.2
|
|
gptkbp:medicalUse
|
recombinant IGF1 used to treat growth failure
|
|
gptkbp:molecularWeight
|
7.6 kDa
|
|
gptkbp:mutationAssociatedWith
|
deafness
insulin resistance
developmental delay
growth retardation
|
|
gptkbp:OMIM
|
147440
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Igf1
rat Igf1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1IMX
|
|
gptkbp:producedBy
|
liver
other tissues
|
|
gptkbp:recipient
|
gptkb:IGF1R
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
metabolism
recombinant human growth hormone
|
|
gptkbp:structureType
|
single-chain polypeptide
|
|
gptkbp:symbol
|
gptkb:IGF1
|
|
gptkbp:UniProtID
|
P05019
|
|
gptkbp:bfsParent
|
gptkb:IGFBP3
gptkb:insulin-like_growth_factors
|
|
gptkbp:bfsLayer
|
7
|