Insulin-like growth factor 1 receptor

URI: https://gptkb.org/entity/Insulin-like_growth_factor_1_receptor
GPTKB entity
Statements (35)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeSplicing yes
gptkbp:associatedWith gptkb:cancer
growth disorders
gptkbp:binds gptkb:insulin-like_growth_factor_2
gptkb:insulin-like_growth_factor_1
gptkbp:biologicalProcess cell proliferation
signal transduction
apoptosis regulation
receptor activity
protein tyrosine kinase activity
metabolic process
gptkbp:discoveredBy Shin-ichiro Nakae
gptkbp:discoveredIn 1986
gptkbp:domain extracellular domain
transmembrane domain
intracellular tyrosine kinase domain
gptkbp:encodedBy gptkb:IGF1R_gene
gptkbp:formsComplexWith gptkb:insulin_receptor
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function regulates cell differentiation
regulates cell survival
regulates cell growth
mediates effects of IGF-1
gptkbp:HGNC_ID 5465
https://www.w3.org/2000/01/rdf-schema#label Insulin-like growth factor 1 receptor
gptkbp:locatedIn gptkb:cell_membrane
gptkbp:locatedOnChromosome gptkb:19p13.2
gptkbp:OMIM 147370
gptkbp:subunit heterotetramer (2 alpha, 2 beta chains)
gptkbp:target therapeutic antibodies
gptkbp:UniProtID gptkb:P08069
gptkbp:bfsParent gptkb:IGF-1R
gptkbp:bfsLayer 7