|
gptkbp:instanceOf
|
gptkb:receptor_tyrosine_kinase
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CD221
gptkb:IGF1R
|
|
gptkbp:associatedWith
|
gptkb:cancer
growth disorders
|
|
gptkbp:biologicalProcess
|
cell proliferation
metabolism regulation
apoptosis inhibition
|
|
gptkbp:dimerization
|
forms heterodimers with insulin receptor
forms homodimers
|
|
gptkbp:downstreamOf
|
gptkb:MAPK_pathway
gptkb:PI3K-AKT_pathway
|
|
gptkbp:encodedBy
|
gptkb:IGF1R_gene
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
binds insulin-like growth factor 1
mediates cell differentiation
mediates cell growth
mediates cell survival
mediates cell transformation
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF1 receptor
|
|
gptkbp:inhibitedBy
|
gptkb:linsitinib
gptkb:picropodophyllin
|
|
gptkbp:ligand
|
gptkb:insulin-like_growth_factor_2
gptkb:insulin-like_growth_factor_1
|
|
gptkbp:locatedOnChromosome
|
chromosome 15q26.3
|
|
gptkbp:membraneLocation
|
gptkb:cell_membrane
|
|
gptkbp:mutationAssociatedWith
|
insulin resistance
growth retardation
|
|
gptkbp:OMIM
|
147370
|
|
gptkbp:PDB
|
3D94
|
|
gptkbp:phosphorylates
|
autophosphorylation upon ligand binding
|
|
gptkbp:relatedTo
|
gptkb:insulin_receptor
|
|
gptkbp:reviewedBy
|
gptkb:Cell_Signaling_Technology
gptkb:GeneCards
gptkb:Nature_Reviews_Cancer
|
|
gptkbp:structure
|
cell surface receptor
tyrosine kinase receptor
|
|
gptkbp:subunit
|
alpha and beta subunits
|
|
gptkbp:target
|
anticancer drugs
therapeutic antibodies
|
|
gptkbp:UniProtID
|
gptkb:P08069
|
|
gptkbp:bfsParent
|
gptkb:IGF2
|
|
gptkbp:bfsLayer
|
6
|