tyrosine kinase receptor family

URI: https://gptkb.org/entity/tyrosine_kinase_receptor_family
GPTKB entity
Statements (33)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:activity phosphorylation of tyrosine residues
gptkbp:contains gptkb:insulin_receptor
gptkb:receptor_tyrosine_kinases
gptkb:epidermal_growth_factor_receptor
neurotrophin receptor
fibroblast growth factor receptor
platelet-derived growth factor receptor
vascular endothelial growth factor receptor
gptkbp:discoveredBy gptkb:Stanley_Cohen
gptkbp:discoveredIn 1970s
gptkbp:domain transmembrane domain
extracellular ligand-binding domain
intracellular tyrosine kinase domain
gptkbp:dysregulationAssociatedWith gptkb:cancer
gptkb:diabetes
developmental disorders
gptkbp:function signal transduction
https://www.w3.org/2000/01/rdf-schema#label tyrosine kinase receptor family
gptkbp:ligand growth factors
hormones
gptkbp:location gptkb:cell_membrane
gptkbp:mechanismOfAction autophosphorylation
gptkbp:role cell differentiation
cell survival
cell growth
cell migration
cell metabolism
gptkbp:subclassOf gptkb:receptor_tyrosine_kinase
gptkb:enzyme
gptkbp:bfsParent gptkb:EPHA3
gptkb:IGF-1R
gptkbp:bfsLayer 7