|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Multiplication-stimulating activity (MSA)
Somatomedin A
|
|
gptkbp:associatedWith
|
gptkb:Wilms_tumor
gptkb:cancer
gptkb:Beckwith-Wiedemann_syndrome
gptkb:Silver-Russell_syndrome
|
|
gptkbp:biologicalProcess
|
cell proliferation
embryonic development
metabolic regulation
|
|
gptkbp:discoveredBy
|
Daughaday et al.
|
|
gptkbp:discoveredIn
|
1970s
|
|
gptkbp:encodedBy
|
gptkb:IGF2_gene
|
|
gptkbp:expressedIn
|
high in fetal tissues
low in adult tissues
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_2
|
|
gptkbp:function
|
growth factor
regulation of cell growth
regulation of development
|
|
gptkbp:gene
|
gptkb:IGF2
|
|
gptkbp:GOID
|
GO:0005159
|
|
gptkbp:HGNC_ID
|
5466
|
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gptkbp:homology
|
similar to IGF-1
similar to insulin
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-2
|
|
gptkbp:imprintingStatus
|
imprinted gene
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_11p15.5_(human)
|
|
gptkbp:medicalUse
|
biomarker for cancer
biomarker for growth disorders
|
|
gptkbp:molecularWeight
|
7.5 kDa
|
|
gptkbp:organism
|
gptkb:human
gptkb:mouse
|
|
gptkbp:orthologIn
|
present in mammals
present in birds
present in fish
|
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gptkbp:PDB
|
gptkb:1IGL
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic processing
|
|
gptkbp:recipient
|
gptkb:insulin_receptor
gptkb:IGF-1_receptor
gptkb:IGF-2_receptor
|
|
gptkbp:regulates
|
epigenetic regulation
parental imprinting
|
|
gptkbp:sequence
|
180 amino acids (precursor)
67 amino acids (mature)
|
|
gptkbp:structure
|
polypeptide
|
|
gptkbp:tissue_specificity
|
gptkb:skeletal_muscle
gptkb:kidney
gptkb:placenta
brain
liver
pancreas
fetal tissues
|
|
gptkbp:UniProtID
|
P01344
|
|
gptkbp:bfsParent
|
gptkb:somatomedin-A
gptkb:IGF-1R
gptkb:insulin-like_growth_factors
gptkb:Insulin-like_Growth_Factor
|
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gptkbp:bfsLayer
|
7
|