IGF-1

GPTKB entity

Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
hormone
gptkbp:alternativeName Somatomedin C
Mechano growth factor
gptkbp:associatedWith gptkb:cancer
gptkb:Laron_syndrome
gptkb:diabetes_mellitus
acromegaly
gptkbp:binds gptkb:IGF-1_receptor
gptkbp:category growth factor
endocrine hormone
gptkbp:discoveredBy D.R. Rinderknecht
gptkbp:discoveredIn 1978
gptkbp:foundIn blood plasma
cerebrospinal fluid
gptkbp:fullName gptkb:Insulin-like_growth_factor_1
gptkbp:function inhibits apoptosis
regulates cell growth and development
stimulates systemic body growth
gptkbp:gene gptkb:IGF1
gptkbp:halfLife 12-15 hours
gptkbp:HGNC_ID 5464
https://www.w3.org/2000/01/rdf-schema#label IGF-1
gptkbp:inhibitedBy gptkb:IGF_binding_proteins
gptkbp:locatedOnChromosome 12q23.2
gptkbp:medicalUse diagnosis of growth disorders
treatment of growth hormone insensitivity
gptkbp:molecularWeight 7.6 kDa
gptkbp:OMIM 147440
gptkbp:PDB 1IMX
gptkbp:producedBy liver
peripheral tissues
gptkbp:promotion recombinant human growth hormone
gptkbp:recipient tyrosine kinase receptor
gptkbp:regulates gptkb:insulin
nutritional status
sex steroids
gptkbp:relatedTo gptkb:insulin
gptkb:IGF-2
gptkbp:sequence 70 amino acids
gptkbp:species gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkbp:UniProtID P05019
gptkbp:bfsParent gptkb:IGF-1R
gptkb:insulin-like_growth_factors
gptkb:Insulin-like_Growth_Factor
gptkbp:bfsLayer 7