|
gptkbp:instanceOf
|
gptkb:protein
gptkb:hormone
|
|
gptkbp:alternativeName
|
Somatomedin C
Mechano growth factor
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:Laron_syndrome
gptkb:diabetes_mellitus
acromegaly
|
|
gptkbp:binds
|
gptkb:IGF-1_receptor
|
|
gptkbp:category
|
gptkb:growth_factor
endocrine hormone
|
|
gptkbp:discoveredBy
|
D.R. Rinderknecht
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:foundIn
|
blood plasma
cerebrospinal fluid
|
|
gptkbp:fullName
|
gptkb:Insulin-like_growth_factor_1
|
|
gptkbp:function
|
inhibits apoptosis
regulates cell growth and development
stimulates systemic body growth
|
|
gptkbp:gene
|
gptkb:IGF1
|
|
gptkbp:halfLife
|
12-15 hours
|
|
gptkbp:HGNC_ID
|
5464
|
|
gptkbp:inhibitedBy
|
gptkb:IGF_binding_proteins
|
|
gptkbp:locatedOnChromosome
|
12q23.2
|
|
gptkbp:medicalUse
|
diagnosis of growth disorders
treatment of growth hormone insensitivity
|
|
gptkbp:molecularWeight
|
7.6 kDa
|
|
gptkbp:OMIM
|
147440
|
|
gptkbp:PDB
|
1IMX
|
|
gptkbp:producedBy
|
liver
peripheral tissues
|
|
gptkbp:promotion
|
gptkb:recombinant_human_growth_hormone
|
|
gptkbp:recipient
|
tyrosine kinase receptor
|
|
gptkbp:regulates
|
gptkb:insulin
nutritional status
sex steroids
|
|
gptkbp:relatedTo
|
gptkb:insulin
gptkb:IGF-2
|
|
gptkbp:sequence
|
70 amino acids
|
|
gptkbp:species
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:UniProtID
|
P05019
|
|
gptkbp:bfsParent
|
gptkb:Insulin-like_Growth_Factor
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
IGF-1
|