|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1982
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:form
|
GTP-bound
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
guanine nucleotide exchange factor
signal transduction
|
|
gptkbp:GO_term
|
GO:0005525
GO:0007165
GO:0007265
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
RAS protein
|
|
gptkbp:inactiveForm
|
GDP-bound
|
|
gptkbp:interactsWith
|
gptkb:PI3K
gptkb:RAF_kinase
gptkb:RalGDS
GTPase-activating proteins (GAPs)
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
cell proliferation
|
|
gptkbp:locale
|
inner surface of plasma membrane
|
|
gptkbp:memberOf
|
gptkb:Ras_superfamily
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
colorectal cancer
pancreatic cancer
codon 12
codon 13
codon 61
|
|
gptkbp:OMIM
|
190020
|
|
gptkbp:orthologIn
|
gptkb:C._elegans_let-60
gptkb:Drosophila_Ras85D
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
|
|
gptkbp:regulates
|
gptkb:Ral-GDS_pathway
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
|
|
gptkbp:structure
|
contains G domain
contains switch I and II regions
|
|
gptkbp:subfamily
|
small molecule
|
|
gptkbp:target
|
anticancer drug research
|
|
gptkbp:UniProtID
|
gptkb:P01112
|
|
gptkbp:bfsParent
|
gptkb:RAF_kinase
|
|
gptkbp:bfsLayer
|
5
|