|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
guanine nucleotide exchange factors (GEFs)
|
|
gptkbp:binds
|
gptkb:GDP
gptkb:GTP
|
|
gptkbp:biologicalProcess
|
signal transduction
|
|
gptkbp:category
|
gptkb:cell_membrane
gptkb:G_protein-coupled_receptor
signal transduction protein
oncoprotein
|
|
gptkbp:decommissioned
|
GTPase-activating proteins (GAPs)
|
|
gptkbp:discoveredBy
|
gptkb:Harold_E._Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:encodedBy
|
gptkb:HRAS_gene
gptkb:NRAS_gene
gptkb:KRAS_gene
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:function
|
guanine nucleotide exchange factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Ras proteins
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_pathway
gptkb:PI3K/AKT_pathway
cell signaling
|
|
gptkbp:location
|
inner surface of plasma membrane
|
|
gptkbp:member
|
gptkb:HRAS
gptkb:KRAS
gptkb:NRAS
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Costello_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:orthologIn
|
Ras-related proteins
|
|
gptkbp:PDB
|
gptkb:5P21
|
|
gptkbp:postTranslationalModification
|
farnesylation
palmitoylation
prenylation
|
|
gptkbp:proteinFamily
|
gptkb:RAS_gene_family
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
tumor suppressor
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
gptkbp:structure
|
small molecule
|
|
gptkbp:target
|
biological research
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P01111
gptkb:P01112
gptkb:P01116
|
|
gptkbp:bfsParent
|
gptkb:Ras_gene_family
|
|
gptkbp:bfsLayer
|
5
|