Glycogen synthase kinase-3

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:GSK-3
gptkbp:associatedWith	gptkb:Alzheimer's_disease gptkb:cancer gptkb:diabetes_mellitus bipolar disorder
gptkbp:discoveredBy	gptkb:Dale_E._Krebs
gptkbp:discoveredIn	1980
gptkbp:encodedBy	gptkb:GSK3A gptkb:GSK3B
gptkbp:enzymeClassification	EC 2.7.11.26
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	regulation of apoptosis regulation of cell proliferation regulation of Wnt signaling pathway regulation of glucose metabolism phosphorylation of glycogen synthase
gptkbp:GO_term	GO:0004672 GO:0006468
gptkbp:hasIsoform	gptkb:GSK-3α gptkb:GSK-3β
https://www.w3.org/2000/01/rdf-schema#label	Glycogen synthase kinase-3
gptkbp:inhibitedBy	gptkb:SB-216763 gptkb:Tideglusib gptkb:CHIR99021 lithium AR-A014418
gptkbp:locatedOnChromosome	chromosome 19 (GSK3A) chromosome 3 (GSK3B)
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:molecularWeight	47 kDa 46 kDa
gptkbp:orthologIn	gptkb:Drosophila_shaggy
gptkbp:PDB	gptkb:1PYX gptkb:1Q4L
gptkbp:regulates	activated by phosphorylation at tyrosine inhibited by phosphorylation at serine
gptkbp:substrate	gptkb:glycogen_synthase gptkb:tau_protein gptkb:β-catenin
gptkbp:UniProtID	gptkb:P49840 gptkb:P49841
gptkbp:bfsParent	gptkb:GSK-3
gptkbp:bfsLayer	7