|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:Grb-2
gptkb:Growth_factor_receptor-bound_protein_2
gptkb:ASH
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:BCR-ABL
gptkb:EGFR
gptkb:SHC1
gptkb:cancer
gptkb:Noonan_syndrome
gptkb:SOS1
colorectal cancer
leukemia
|
|
gptkbp:discoveredBy
|
Lowenstein et al.
|
|
gptkbp:discoveredIn
|
1992
|
|
gptkbp:domain
|
SH2 domain
SH3 domain
|
|
gptkbp:encodes
|
gptkb:GRB2_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000177885
2885
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
gptkb:Growth_factor_receptor-bound_protein_2
|
|
gptkbp:function
|
adaptor protein in signal transduction
links receptor tyrosine kinases to Ras signaling pathway
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
4566
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
GRB2 gene
|
|
gptkbp:interactsWith
|
gptkb:BCR-ABL
gptkb:EGFR
gptkb:SHC1
gptkb:SOS1
|
|
gptkbp:length
|
217 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_17
17q25.1
|
|
gptkbp:molecularWeight
|
25 kDa
|
|
gptkbp:mutationAssociatedWith
|
can alter cell proliferation
|
|
gptkbp:OMIM
|
108355
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:UniProtID
|
gptkb:P62993
|
|
gptkbp:bfsParent
|
gptkb:GRB2
|
|
gptkbp:bfsLayer
|
6
|