Fibroblast growth factor receptor 4

URI: https://gptkb.org/entity/Fibroblast_growth_factor_receptor_4
GPTKB entity
Statements (45)
Predicate Object
gptkbp:instanceOf gptkb:receptor_tyrosine_kinase
gptkb:protein
gptkbp:alternativeName gptkb:CD334
FGFR-4
gptkbp:associatedWith gptkb:cancer
muscle development
gptkbp:biologicalProcess cell differentiation
cell proliferation
protein tyrosine kinase activity
fibroblast growth factor binding
gptkbp:cellularComponent gptkb:plasma_membrane
gptkbp:domain protein kinase domain
immunoglobulin-like domain
gptkbp:EC_number 2.7.10.1
gptkbp:encodedBy gptkb:FGFR4_gene
gptkbp:Entrez_Gene_ID 2264
ENSG00000160867
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:hasPolymorphism G388R
gptkbp:hasRefSeqID NM_002011
gptkbp:HGNC_ID HGNC:3686
https://www.w3.org/2000/01/rdf-schema#label Fibroblast growth factor receptor 4
gptkbp:interactsWith gptkb:fibroblast_growth_factors
gptkbp:length 802 amino acids
gptkbp:ligand gptkb:FGF1
gptkb:FGF2
gptkb:FGF23
gptkb:FGF6
gptkb:FGF8
gptkb:FGF19
gptkb:FGF4
gptkbp:locatedOnChromosome 5q35.2-qter
gptkbp:memberOf gptkb:FGFR_family
gptkbp:molecularWeight 95 kDa
gptkbp:OMIM 134935
gptkbp:pathway gptkb:RAS_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:FGF_signaling_pathway
gptkbp:PDB 4UXQ
gptkbp:significance prognostic marker in cancer
gptkbp:target cancer therapeutics
gptkbp:UniProtID P22455
gptkbp:bfsParent gptkb:FGFR4
gptkbp:bfsLayer 6