Fibroblast growth factor receptor 4

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:receptor_tyrosine_kinase gptkb:protein
gptkbp:alternativeName	gptkb:CD334 FGFR-4
gptkbp:associatedWith	gptkb:cancer muscle development
gptkbp:biologicalProcess	cell differentiation cell proliferation protein tyrosine kinase activity fibroblast growth factor binding
gptkbp:cellularComponent	gptkb:plasma_membrane
gptkbp:domain	protein kinase domain immunoglobulin-like domain
gptkbp:EC_number	2.7.10.1
gptkbp:encodedBy	gptkb:FGFR4_gene
gptkbp:Entrez_Gene_ID	2264 ENSG00000160867
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:hasPolymorphism	G388R
gptkbp:hasRefSeqID	NM_002011
gptkbp:HGNC_ID	HGNC:3686
gptkbp:interactsWith	gptkb:fibroblast_growth_factors
gptkbp:length	802 amino acids
gptkbp:ligand	gptkb:FGF1 gptkb:FGF2 gptkb:FGF23 gptkb:FGF6 gptkb:FGF8 gptkb:FGF19 gptkb:FGF4
gptkbp:locatedOnChromosome	5q35.2-qter
gptkbp:memberOf	gptkb:FGFR_family
gptkbp:molecularWeight	95 kDa
gptkbp:OMIM	134935
gptkbp:pathway	gptkb:RAS_signaling_pathway gptkb:MAPK_signaling_pathway gptkb:PI3K-Akt_signaling_pathway gptkb:FGF_signaling_pathway
gptkbp:PDB	4UXQ
gptkbp:significance	prognostic marker in cancer
gptkbp:target	cancer therapeutics
gptkbp:UniProtID	P22455
gptkbp:bfsParent	gptkb:FGFR4
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Fibroblast growth factor receptor 4