|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:TKF
gptkb:CD334
gptkb:JTK2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:rhabdomyosarcoma
prostate cancer
hepatocellular carcinoma
|
|
gptkbp:chromosomeArm
|
q
|
|
gptkbp:discoveredBy
|
Powers et al.
|
|
gptkbp:discoveredIn
|
1989
|
|
gptkbp:domain
|
immunoglobulin-like domain
tyrosine kinase domain
|
|
gptkbp:encodes
|
gptkb:FGFR4_protein
|
|
gptkbp:Entrez_Gene_ID
|
2264
ENSG00000160867
GC04P022455
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:skeletal_muscle
gptkb:kidney
gptkb:testis
liver
|
|
gptkbp:family
|
fibroblast growth factor receptor family
|
|
gptkbp:fullName
|
gptkb:Fibroblast_growth_factor_receptor_4
|
|
gptkbp:function
|
gptkb:receptor_tyrosine_kinase
binds fibroblast growth factors
|
|
gptkbp:HGNC_ID
|
HGNC:3686
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGFR4
|
|
gptkbp:involvedIn
|
cell differentiation
cell proliferation
wound healing
angiogenesis
|
|
gptkbp:locatedOnChromosome
|
5
5q35.2
|
|
gptkbp:membrane_protein
|
yes
|
|
gptkbp:mutationAssociatedWith
|
G388R
|
|
gptkbp:OMIM
|
134935
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Fgfr4
rat Fgfr4
|
|
gptkbp:PDB
|
4UXQ
|
|
gptkbp:phosphorylates
|
yes
|
|
gptkbp:Reactome
|
R-HSA-190236
|
|
gptkbp:signal_transduction
|
yes
|
|
gptkbp:transmembraneDomains
|
yes
|
|
gptkbp:UniProtID
|
P22455
|
|
gptkbp:bfsParent
|
gptkb:Lenvima
|
|
gptkbp:bfsLayer
|
5
|