|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
FGF-19
Fibroblast growth factor 19
UNQ828/PRO1759
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:clinicalTrialPhase
|
liver diseases
metabolic diseases
|
|
gptkbp:discoveredIn
|
1999
|
|
gptkbp:downregulatedIn
|
gptkb:CYP7A1
|
|
gptkbp:encodedBy
|
gptkb:FGF19_gene
|
|
gptkbp:Entrez_Gene_ID
|
9965
ENSG00000102466
|
|
gptkbp:expressedIn
|
liver
ileum
|
|
gptkbp:family
|
gptkb:fibroblast_growth_factor_family
|
|
gptkbp:fullName
|
Fibroblast growth factor 19
|
|
gptkbp:function
|
regulation of glucose metabolism
regulation of lipid metabolism
regulation of bile acid synthesis
|
|
gptkbp:HGNC_ID
|
3680
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGF19
|
|
gptkbp:length
|
216 amino acids
|
|
gptkbp:locatedOnChromosome
|
11q13.1
|
|
gptkbp:molecularWeight
|
23.5 kDa
|
|
gptkbp:mutationAssociatedWith
|
metabolic disorders
altered bile acid metabolism
|
|
gptkbp:OMIM
|
603891
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Fgf15
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
bile acid homeostasis
FGF19-FGFR4 signaling pathway
|
|
gptkbp:PDB
|
2P23
|
|
gptkbp:pharmaceuticalInterest
|
potential therapeutic target
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:recipient
|
gptkb:FGFR4
beta-Klotho
|
|
gptkbp:regulates
|
gptkb:farnesoid_X_receptor_(FXR)
|
|
gptkbp:role
|
gptkb:metabolic_syndrome
hepatocellular carcinoma
cholestatic liver disease
|
|
gptkbp:secretes
|
yes
|
|
gptkbp:tissue_specificity
|
high in small intestine
|
|
gptkbp:UniProtID
|
O95750
|
|
gptkbp:bfsParent
|
gptkb:chromosome_11q13.1
gptkb:CD331
gptkb:Fibroblast_growth_factor_receptor_4
|
|
gptkbp:bfsLayer
|
7
|