fibroblast growth factors

URI: https://gptkb.org/entity/fibroblast_growth_factors
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation FGFs
gptkbp:alternativeName heparin-binding growth factors
gptkbp:binds FGF receptors
gptkbp:cofactor gptkb:heparan_sulfate_proteoglycans
gptkbp:discoveredBy Trowell and Willmer
gptkbp:example gptkb:FGF1
gptkb:FGF2
gptkb:FGF7
gptkb:FGF10
gptkb:FGF5
gptkb:FGF8
gptkb:FGF3
gptkb:FGF4
gptkbp:firstDescribed 1970s
gptkbp:function embryonic development
angiogenesis
cell growth regulation
tissue repair
https://www.w3.org/2000/01/rdf-schema#label fibroblast growth factors
gptkbp:involvedIn wound healing
neurogenesis
tumorigenesis
limb development
gptkbp:locatedOnChromosome various chromosomes
gptkbp:location extracellular matrix
cell surface
gptkbp:medicalUse therapeutic agents in regenerative medicine
gptkbp:memberOf growth factor superfamily
gptkbp:molecularWeight 17-34 kDa
gptkbp:mutationAssociatedWith can cause cancer
can cause developmental disorders
gptkbp:numberOfMembers 22 in humans
gptkbp:orthologIn present in C. elegans
present in Drosophila
gptkbp:pathway gptkb:PLCĪ³_pathway
gptkb:STAT_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkbp:proteinFamily FGF gene family
gptkbp:recipient gptkb:receptor_tyrosine_kinases
gptkbp:regulates regulated by heparan sulfate
gptkbp:role cancer progression
skeletal dysplasia
craniosynostosis syndromes
gptkbp:species found in invertebrates
found in vertebrates
gptkbp:structure beta-trefoil fold
gptkbp:bfsParent gptkb:FGFR
gptkbp:bfsLayer 6