|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:tumor-induced_osteomalacia
familial tumoral calcinosis
hypophosphatemic rickets
|
|
gptkbp:category
|
growth factor
signaling molecule
endocrine hormone
|
|
gptkbp:cofactor
|
Klotho
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:downregulatedIn
|
1,25-dihydroxyvitamin D production
|
|
gptkbp:encodedBy
|
FGF23 gene
|
|
gptkbp:Entrez_Gene_ID
|
80710
|
|
gptkbp:expressedIn
|
bone tissue
|
|
gptkbp:fullName
|
Fibroblast growth factor 23
|
|
gptkbp:function
|
regulation of phosphate homeostasis
regulation of vitamin D metabolism
|
|
gptkbp:gene
|
gptkb:FGF23
|
|
gptkbp:HGNC_ID
|
3667
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FGF23
|
|
gptkbp:inhibitedBy
|
sodium-phosphate cotransporters in kidney
|
|
gptkbp:locatedOnChromosome
|
12p13.3
|
|
gptkbp:molecularWeight
|
32 kDa
|
|
gptkbp:mutationAssociatedWith
|
hyperphosphatemia
autosomal dominant hypophosphatemic rickets
|
|
gptkbp:OMIM
|
606524
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
5W21
|
|
gptkbp:postTranslationalModification
|
glycosylation
proteolytic cleavage
|
|
gptkbp:recipient
|
gptkb:FGFR3
gptkb:FGFR1
gptkb:FGFR4
|
|
gptkbp:regulates
|
parathyroid hormone secretion
1-alpha-hydroxylase activity
renal phosphate reabsorption
vitamin D activation
|
|
gptkbp:relatedTo
|
gptkb:FGF19
gptkb:FGF21
|
|
gptkbp:reviewedBy
|
gptkb:Nature_Genetics
gptkb:Journal_of_Bone_and_Mineral_Research
|
|
gptkbp:secretes
|
osteoblasts
osteocytes
|
|
gptkbp:structure
|
single-chain polypeptide
|
|
gptkbp:UniProtID
|
Q9GZV9
|
|
gptkbp:upregulates
|
phosphate excretion
|
|
gptkbp:bfsParent
|
gptkb:VDR
gptkb:CD331
gptkb:Fibroblast_growth_factor_receptor_4
|
|
gptkbp:bfsLayer
|
7
|