Statements (62)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:bfsLayer |
6
|
| gptkbp:bfsParent |
gptkb:palbociclib
|
| gptkbp:associated_with |
tumorigenesis
|
| gptkbp:code |
CD K6 gene
|
| gptkbp:established |
gptkb:cyclin_E
gptkb:species p16 IN K4a p21 CI P1 retinoblastoma protein |
| gptkbp:has_role |
transcription regulation
|
| https://www.w3.org/2000/01/rdf-schema#label |
cyclin-dependent kinase 6
|
| gptkbp:interacts_with |
gptkb:cyclin_D
|
| gptkbp:is_aimed_at |
small molecule inhibitors
|
| gptkbp:is_associated_with |
cell differentiation
cell migration |
| gptkbp:is_essential_for |
G1/ S transition
|
| gptkbp:is_involved_in |
DNA damage response
apoptosis regulation cell proliferation cellular homeostasis cellular metabolism immune response signal transduction cellular senescence tumorigenesis cell survival tumor microenvironment cellular differentiation cell cycle checkpoints neurogenesis angiogenesis cell adhesion metastasis cellular signaling pathways stem cell maintenance cellular signaling cellular repair mechanisms cellular growth |
| gptkbp:is_linked_to |
gptkb:healthcare_organization
gptkb:cervical_cancer liver cancer cancer progression bladder cancer gastrointestinal cancer |
| gptkbp:is_part_of |
gptkb:CDK_family
cell cycle regulation |
| gptkbp:is_represented_in |
gptkb:healthcare_organization
ovarian cancer esophageal cancer colon cancer head and neck cancer hematopoietic cells neural tissues |
| gptkbp:located_in |
gptkb:physicist
|
| gptkbp:material |
p Rb
|
| gptkbp:regulates |
cell cycle
growth factors phosphorylation CDK inhibitors micro RN As |
| gptkbp:weight |
approximately 34 k Da
|