|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:CDKN6
gptkb:Serine/threonine-protein_kinase_CDK6
gptkb:cyclin-dependent_kinase_6
PLSTIRE
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:biologicalProcess
|
protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
|
|
gptkbp:discoveredBy
|
1994
|
|
gptkbp:Entrez_Gene_ID
|
1021
|
|
gptkbp:enzymeClassification
|
EC 2.7.11.22
|
|
gptkbp:expressedIn
|
high in brain
high in hematopoietic cells
high in testis
|
|
gptkbp:fullName
|
gptkb:Cyclin-dependent_kinase_6
|
|
gptkbp:function
|
regulation of cell cycle
|
|
gptkbp:gene
|
gptkb:CDK6
|
|
gptkbp:HGNC_ID
|
1777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdk6
|
|
gptkbp:inhibitedBy
|
gptkb:p15INK4b
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:p19INK4d
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q21.2
|
|
gptkbp:molecularWeight
|
36 kDa
|
|
gptkbp:OMIM
|
603368
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Cdk6
gptkb:rat_Cdk6
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
cell cycle
p53 signaling pathway
|
|
gptkbp:PDB
|
1BI7
|
|
gptkbp:phosphorylates
|
gptkb:RB1
p107
p130
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:targetOfDrug
|
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:UniProtID
|
gptkb:Q00534
|
|
gptkbp:bfsParent
|
gptkb:CDK6
|
|
gptkbp:bfsLayer
|
7
|