|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CDKN6
MSTP036
PLSTIRE
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
leukemia
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
protein serine/threonine kinase activity
hematopoiesis
|
|
gptkbp:discoveredBy
|
Serrano et al.
|
|
gptkbp:encodes
|
gptkb:Cyclin-dependent_kinase_6
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105810
1021
GC07P092282
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:function
|
regulation of cell cycle
G1/S transition of mitotic cell cycle
|
|
gptkbp:HGNC_ID
|
1777
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDK6 gene
|
|
gptkbp:inhibitedBy
|
gptkb:p16INK4a
gptkb:p18INK4c
gptkb:palbociclib
gptkb:ribociclib
gptkb:abemaciclib
|
|
gptkbp:interactsWith
|
gptkb:Cyclin_D2
gptkb:Cyclin_D3
gptkb:Cyclin_D1
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_7
gptkb:7q21.2
|
|
gptkbp:mutationAssociatedWith
|
tumorigenesis
|
|
gptkbp:OMIM
|
603368
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdk6
|
|
gptkbp:pathway
|
gptkb:PI3K-Akt_signaling_pathway
p53 signaling pathway
cell cycle pathway
|
|
gptkbp:PDB
|
gptkb:1G3N
|
|
gptkbp:proteinFamily
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:RefSeq
|
gptkb:NM_001259
|
|
gptkbp:regulates
|
regulated by microRNAs
transcriptional regulation by E2F
|
|
gptkbp:UniProtID
|
gptkb:Q00534
|
|
gptkbp:bfsParent
|
gptkb:CDK6
|
|
gptkbp:bfsLayer
|
7
|