CREB (cAMP response element-binding protein)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein transcription factor
gptkbp:activatedBy	phosphorylation
gptkbp:alias	gptkb:CREB1 gptkb:cAMP_response_element-binding_protein
gptkbp:associatedWith	gptkb:cancer gptkb:depression gptkb:long-term_potentiation drug addiction learning and memory
gptkbp:binds	gptkb:cAMP_response_element_(CRE)
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:CREB1_gene
gptkbp:Entrez_Gene_ID	1385
gptkbp:formsComplexWith	gptkb:CBP_(CREB-binding_protein) gptkb:p300
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	regulation of gene expression cellular response to cAMP
https://www.w3.org/2000/01/rdf-schema#label	CREB (cAMP response element-binding protein)
gptkbp:involvedIn	cell survival neuronal plasticity memory formation
gptkbp:locale	gptkb:nucleus
gptkbp:locatedOnChromosome	2q34
gptkbp:molecularWeight	~43 kDa
gptkbp:OMIM	123810
gptkbp:phosphorylates	gptkb:Ca2+/calmodulin-dependent_protein_kinases mitogen-activated protein kinases (MAPK) protein kinase A (PKA)
gptkbp:regulates	gptkb:cyclin_D1 gptkb:NR4A1 gptkb:somatostatin gptkb:vasopressin gptkb:insulin_gene gptkb:tyrosine_hydroxylase gptkb:BDNF_(brain-derived_neurotrophic_factor) gptkb:enkephalin transcription of target genes SOM (somatostatin) c-fos c-jun glucagon gene proopiomelanocortin (POMC)
gptkbp:speciesHomologs	gptkb:mouse gptkb:Drosophila_melanogaster right
gptkbp:structure	contains basic leucine zipper (bZIP) domain
gptkbp:UniProtID	P16220
gptkbp:bfsParent	gptkb:cAMP_pathway
gptkbp:bfsLayer	6