cAMP response element-binding protein

URI: https://gptkb.org/entity/cAMP_response_element-binding_protein

GPTKB entity

Statements (51)

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:abbreviation	gptkb:CREB
gptkbp:activatedBy	phosphorylation
gptkbp:alternativeSplicing	yes
gptkbp:binds	gptkb:cAMP_response_element_(CRE)
gptkbp:discoveredIn	1987
gptkbp:encodedBy	gptkb:CREB1_gene
gptkbp:Entrez_Gene_ID	1385
gptkbp:expressedIn	gptkb:skeletal_muscle brain liver various tissues
gptkbp:formsComplexWith	gptkb:CBP_(CREB-binding_protein)
gptkbp:formsHeterodimerWith	other bZIP proteins
gptkbp:foundIn	gptkb:nucleus
gptkbp:function	transcription factor
https://www.w3.org/2000/01/rdf-schema#label	cAMP response element-binding protein
gptkbp:involvedIn	gptkb:long-term_potentiation neuronal plasticity memory formation
gptkbp:length	341 amino acids
gptkbp:locatedOnChromosome	2q34
gptkbp:molecularWeight	~43 kDa
gptkbp:mutationAssociatedWith	gptkb:depression gptkb:Rubinstein-Taybi_syndrome neurodegenerative diseases cognitive disorders
gptkbp:orthologIn	invertebrates vertebrates
gptkbp:phosphorylates	gptkb:protein_kinase_A gptkb:Ca2+/calmodulin-dependent_protein_kinases Serine 133
gptkbp:regulates	gptkb:BDNF_gene gptkb:c-fos_gene gptkb:somatostatin_gene gptkb:tyrosine_hydroxylase_gene gene expression genes involved in cell survival genes involved in metabolism genes involved in circadian rhythm genes involved in immune response genes involved in neuronal development
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens gptkb:Rattus_norvegicus
gptkbp:structure	basic region leucine zipper domain
gptkbp:UniProtID	P16220
gptkbp:bfsParent	gptkb:CREB gptkb:CREB_(cAMP_response_element-binding_protein)
gptkbp:bfsLayer	7