|
gptkbp:instanceOf
|
gptkb:signaling_molecule
|
|
gptkbp:activatedBy
|
gptkb:protein_kinase_A
|
|
gptkbp:alsoKnownAs
|
gptkb:cyclic_AMP_pathway
|
|
gptkbp:component
|
gptkb:G_proteins
gptkb:cAMP
gptkb:CREB_(cAMP_response_element-binding_protein)
gptkb:protein_kinase_A
adenylyl cyclase
phosphodiesterase
|
|
gptkbp:discoveredBy
|
gptkb:Earl_Sutherland
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
gptkb:depression
heart failure
|
|
gptkbp:endDate
|
phosphodiesterase activity
|
|
gptkbp:firstDescribed
|
1958
|
|
gptkbp:importantFor
|
hormone signaling
neurotransmitter signaling
regulation of ion channels
|
|
gptkbp:involves
|
gptkb:G_protein-coupled_receptors
|
|
gptkbp:launched
|
activation of adenylyl cyclase
|
|
gptkbp:mediatedBy
|
gptkb:cyclic_adenosine_monophosphate
|
|
gptkbp:modulatedBy
|
phosphodiesterase inhibitors
G protein-coupled receptor agonists
G protein-coupled receptor antagonists
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
gene expression
lipid metabolism
metabolism
glycogen metabolism
learning and memory
immune cell function
insulin secretion
CREB phosphorylation
cardiac contractility
cellular response to hormones
smooth muscle relaxation
water reabsorption in kidneys
|
|
gptkbp:target
|
gptkb:glucagon
gptkb:theophylline
gptkb:forskolin
gptkb:vasopressin
caffeine
adrenaline
dopamine
beta-adrenergic agonists
|
|
gptkbp:bfsParent
|
gptkb:RAS2
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
cAMP pathway
|