Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
signaling molecule
|
| gptkbp:activatedBy |
gptkb:protein_kinase_A
|
| gptkbp:alsoKnownAs |
gptkb:cyclic_AMP_pathway
|
| gptkbp:component |
gptkb:G_proteins
gptkb:cAMP gptkb:CREB_(cAMP_response_element-binding_protein) gptkb:protein_kinase_A adenylyl cyclase phosphodiesterase |
| gptkbp:discoveredBy |
gptkb:Earl_Sutherland
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
gptkb:depression heart failure |
| gptkbp:endDate |
phosphodiesterase activity
|
| gptkbp:firstDescribed |
1958
|
| https://www.w3.org/2000/01/rdf-schema#label |
cAMP pathway
|
| gptkbp:importantFor |
hormone signaling
neurotransmitter signaling regulation of ion channels |
| gptkbp:involves |
gptkb:G_protein-coupled_receptors
|
| gptkbp:launched |
activation of adenylyl cyclase
|
| gptkbp:mediatedBy |
gptkb:cyclic_adenosine_monophosphate
|
| gptkbp:modulatedBy |
phosphodiesterase inhibitors
G protein-coupled receptor agonists G protein-coupled receptor antagonists |
| gptkbp:regulates |
apoptosis
cell proliferation gene expression lipid metabolism metabolism glycogen metabolism learning and memory immune cell function insulin secretion CREB phosphorylation cardiac contractility cellular response to hormones smooth muscle relaxation water reabsorption in kidneys |
| gptkbp:target |
gptkb:glucagon
gptkb:theophylline gptkb:forskolin gptkb:vasopressin caffeine adrenaline dopamine beta-adrenergic agonists |
| gptkbp:bfsParent |
gptkb:G_protein-coupled_receptor
|
| gptkbp:bfsLayer |
5
|