|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:activatedBy
|
phosphorylation
|
|
gptkbp:alias
|
gptkb:CREB
gptkb:cAMP_response_element-binding_protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:depression
|
|
gptkbp:binds
|
gptkb:cAMP_response_element_(CRE)
|
|
gptkbp:discoveredBy
|
gptkb:Yamamoto_et_al.
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:domain
|
gptkb:bZIP_domain
Q-rich domain
|
|
gptkbp:encodes
|
CREB protein
|
|
gptkbp:Entrez_Gene_ID
|
1385
ENSG00000118260
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
various tissues
|
|
gptkbp:fullName
|
cAMP responsive element binding protein 1
|
|
gptkbp:function
|
transcription factor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
2346
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CREB1
|
|
gptkbp:interactsWith
|
gptkb:CREM
gptkb:CBP_(CREB-binding_protein)
ATF proteins
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
neuronal plasticity
memory formation
|
|
gptkbp:length
|
341 amino acids
|
|
gptkbp:locatedOnChromosome
|
2q34
|
|
gptkbp:molecularWeight
|
36.7 kDa
|
|
gptkbp:OMIM
|
123810
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInFruitFly
|
CrebB
|
|
gptkbp:orthologInMouse
|
Creb1
|
|
gptkbp:orthologInZebrafish
|
creb1a
|
|
gptkbp:phosphorylates
|
gptkb:protein_kinase_A
gptkb:Ca2+/calmodulin-dependent_protein_kinases
|
|
gptkbp:product
|
CREB1 protein
|
|
gptkbp:regulates
|
positive
gene expression
|
|
gptkbp:transcriptionStartSite
|
chr2:207,529,563 (GRCh38)
|
|
gptkbp:UniProtID
|
P16220
|
|
gptkbp:bfsParent
|
gptkb:CREB_(cAMP_response_element-binding_protein)
gptkb:ATF1
gptkb:EWSR1
|
|
gptkbp:bfsLayer
|
7
|