|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:activatedBy
|
growth factors
phorbol esters
stress signals
|
|
gptkbp:alsoKnownAs
|
gptkb:TR3
gptkb:NGFI-B
gptkb:Nuclear_receptor_subfamily_4_group_A_member_1
gptkb:Nur77
|
|
gptkbp:associatedWith
|
gptkb:cancer
autoimmune diseases
metabolic disorders
|
|
gptkbp:binds
|
gptkb:gene
gptkb:NGFI-B_response_element_(NBRE)
|
|
gptkbp:discoveredBy
|
independent groups in the 1980s
|
|
gptkbp:encodes
|
gptkb:Nuclear_receptor_subfamily_4_group_A_member_1_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105976
3164
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
many tissues
immune cells
|
|
gptkbp:function
|
transcription factor
involved in inflammation
regulates gene expression
involved in apoptosis
involved in T-cell receptor signaling
involved in metabolism
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
7989
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NR4A1
|
|
gptkbp:interactsWith
|
gptkb:Bcl-2
gptkb:RXR_(Retinoid_X_Receptor)
other nuclear receptors
|
|
gptkbp:length
|
598 amino acids (human protein)
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_12
12q13.13
|
|
gptkbp:memberOf
|
nuclear receptor family
|
|
gptkbp:molecularWeight
|
~64 kDa (human protein)
|
|
gptkbp:orthologInMouse
|
gptkb:Nr4a1
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
acetylation
|
|
gptkbp:regulates
|
gptkb:NR4A
apoptosis
cell proliferation
cell survival
inflammatory response
metabolic processes
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P22736
|
|
gptkbp:bfsParent
|
gptkb:NR4
gptkb:MYB_proto-oncogene,_transcription_factor
gptkb:CREB_(cAMP_response_element-binding_protein)
gptkb:Nuclear_receptor_superfamily
gptkb:Aatf
|
|
gptkbp:bfsLayer
|
7
|