BDNF (brain-derived neurotrophic factor)
GPTKB entity
Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
neurotrophin |
| gptkbp:affects |
gptkb:basal_forebrain
gptkb:cortex hippocampus |
| gptkbp:discoveredBy |
gptkb:Yves-Alain_Barde
|
| gptkbp:discoveredIn |
1982
|
| gptkbp:encodedBy |
gptkb:BDNF_gene
|
| gptkbp:foundIn |
brain
peripheral nervous system |
| gptkbp:function |
supports survival of existing neurons
involved in synaptic plasticity encourages growth and differentiation of new neurons and synapses |
| https://www.w3.org/2000/01/rdf-schema#label |
BDNF (brain-derived neurotrophic factor)
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_11_(human)
|
| gptkbp:recipient |
gptkb:p75NTR
gptkb:TrkB |
| gptkbp:regulates |
exercise increases BDNF levels
stress decreases BDNF levels |
| gptkbp:relatedTo |
gptkb:Alzheimer's_disease
gptkb:Parkinson's_disease gptkb:depression gptkb:Huntington's_disease gptkb:autism_spectrum_disorder gptkb:long-term_potentiation addiction bipolar disorder epilepsy memory schizophrenia learning obesity neurodegenerative diseases pain modulation cognitive function sleep eating disorders plasticity stroke recovery neurogenesis anxiety disorders axon growth dendrite growth mood regulation antidepressant response synaptogenesis Val66Met polymorphism |
| gptkbp:UniProtID |
gptkb:P23560
|
| gptkbp:bfsParent |
gptkb:CREB_(cAMP_response_element-binding_protein)
|
| gptkbp:bfsLayer |
7
|