|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:EP300
gptkb:E1A_binding_protein_p300
|
|
gptkbp:coactivatorFor
|
gptkb:CREB
gptkb:HIF1A
gptkb:p53
gptkb:NF-κB
nuclear hormone receptors
|
|
gptkbp:encodedBy
|
EP300 gene
|
|
gptkbp:Entrez_Gene_ID
|
2033
|
|
gptkbp:enzymeCommissionNumber
|
EC 2.3.1.48
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
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gptkbp:foundIn
|
gptkb:Homo_sapiens
|
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gptkbp:function
|
transcriptional co-activator
histone acetyltransferase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p300
|
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gptkbp:interactsWith
|
gptkb:STAT1
gptkb:HIF1A
gptkb:p53
gptkb:NCOA1
CREB-binding protein (CBP)
|
|
gptkbp:involvedIn
|
apoptosis
cell differentiation
DNA repair
cell cycle progression
cell growth
regulation of gene expression
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_22q13.2
|
|
gptkbp:molecularWeight
|
~300 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:Rubinstein-Taybi_syndrome
|
|
gptkbp:OMIM
|
602700
|
|
gptkbp:orthologIn
|
Mus musculus (mouse)
Drosophila melanogaster (nejire)
|
|
gptkbp:PDB
|
gptkb:4PZS
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:regulates
|
gptkb:RNA_polymerase_II
transcription factors
chromatin structure
|
|
gptkbp:requires
|
embryonic development
cellular homeostasis
|
|
gptkbp:structure
|
contains CH1, CH2, CH3 domains
contains HAT domain
contains KIX domain
contains bromodomain
|
|
gptkbp:UniProtID
|
gptkb:Q09472
|
|
gptkbp:bfsParent
|
gptkb:CREB
gptkb:E1A
gptkb:Androgen_receptor
gptkb:CREB_(cAMP_response_element-binding_protein)
gptkb:ZEB1
gptkb:Histone_acetyltransferase
gptkb:EGR1_protein
gptkb:RUNX1
|
|
gptkbp:bfsLayer
|
7
|