|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CREB
gptkb:cAMP_response_element-binding_protein
cAMP-responsive element-binding protein 1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:chromosomeArm
|
2q34
|
|
gptkbp:discoveredBy
|
gptkb:Yamamoto_et_al.
|
|
gptkbp:discoveredIn
|
1988
|
|
gptkbp:encodes
|
CREB protein
|
|
gptkbp:Entrez_Gene_ID
|
1385
ENSG00000118260
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
liver
various tissues
|
|
gptkbp:fullName
|
cAMP responsive element binding protein 1
|
|
gptkbp:function
|
gptkb:transcription_factor
binds cAMP response elements
|
|
gptkbp:HGNC_ID
|
2346
|
|
gptkbp:interactsWith
|
gptkb:CBP_(CREB-binding_protein)
ATF proteins
|
|
gptkbp:involvedIn
|
cell proliferation
cell survival
neuronal plasticity
memory formation
|
|
gptkbp:locatedOnChromosome
|
2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:major_depressive_disorder
|
|
gptkbp:OMIM
|
123810
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Creb1
|
|
gptkbp:pathway
|
gptkb:MAPK_signaling_pathway
gptkb:cAMP_signaling_pathway
gptkb:neurotrophin_signaling_pathway
insulin signaling pathway
|
|
gptkbp:product
|
CREB1 protein
|
|
gptkbp:proteinFamily
|
gptkb:bZIP_domain
KID domain
Q1 and Q2 domains
|
|
gptkbp:regulates
|
gptkb:cAMP_signaling_pathway
gene expression
growth factors
stress signals
calcium signaling
|
|
gptkbp:transcriptionRegulationBy
|
phosphorylation
|
|
gptkbp:UniProtID
|
P16220
|
|
gptkbp:bfsParent
|
gptkb:CREB
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CREB1 gene
|