|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
produces multiple isoforms
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:catalyzes
|
conversion of L-tyrosine to L-DOPA
|
|
gptkbp:cofactor
|
gptkb:tetrahydrobiopterin
iron
|
|
gptkbp:discoveredBy
|
1964
|
|
gptkbp:EC_number
|
1.14.16.2
|
|
gptkbp:expressedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:foundIn
|
gptkb:adrenal_medulla
catecholaminergic neurons
|
|
gptkbp:gene
|
TH
|
|
gptkbp:inhibitedBy
|
gptkb:alpha-methyl-p-tyrosine
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:molecularWeight
|
~60 kDa (monomer)
|
|
gptkbp:product
|
gptkb:L-DOPA
|
|
gptkbp:rate-limiting_enzyme_in
|
catecholamine biosynthesis
|
|
gptkbp:regulates
|
phosphorylation
feedback inhibition by catecholamines
|
|
gptkbp:requires
|
gptkb:ferrous_iron_(Fe2+)
molecular oxygen
|
|
gptkbp:structure
|
homotetramer
|
|
gptkbp:substrate
|
gptkb:L-tyrosine
|
|
gptkbp:UniProtID
|
P07101
|
|
gptkbp:used_as_marker_for
|
dopaminergic neurons
|
|
gptkbp:bfsParent
|
gptkb:L-DOPA
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
tyrosine hydroxylase
|