CBP (CREB-binding protein)

URI: https://gptkb.org/entity/CBP_(CREB-binding_protein)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:CREBBP
gptkb:KAT3A
gptkbp:associatedWith gptkb:Rubinstein-Taybi_syndrome
gptkbp:coactivatorFor gptkb:CREB
gptkb:NF-kB
gptkb:p53
nuclear hormone receptors
gptkbp:domain gptkb:ZZ_domain
gptkb:HAT_domain
gptkb:KIX_domain
gptkb:TAZ_domain
gptkb:bromodomain
gptkbp:encodedBy CREBBP gene
gptkbp:Entrez_Gene_ID 1387
gptkbp:enzymeCommissionNumber EC 2.3.1.48
gptkbp:firstDescribed 1993
gptkbp:function histone acetyltransferase
transcriptional coactivator
https://www.w3.org/2000/01/rdf-schema#label CBP (CREB-binding protein)
gptkbp:interactsWith gptkb:CREB
gptkb:STAT_proteins
gptkb:NF-kB
gptkb:p53
nuclear receptors
gptkbp:locale gptkb:nucleus
gptkbp:locatedOnChromosome 16p13.3
gptkbp:molecularWeight ~265 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
congenital heart defects
intellectual disability
gptkbp:orthologIn gptkb:EP300
gptkbp:postTranslationalModification phosphorylation
acetylation
gptkbp:regulates gene expression
transcription factors
chromatin structure
gptkbp:role apoptosis
cell differentiation
development
DNA repair
cell growth
tumor suppression
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure multi-domain protein
gptkbp:UniProtID gptkb:Q92793
gptkbp:bfsParent gptkb:CREB
gptkb:CREB_(cAMP_response_element-binding_protein)
gptkbp:bfsLayer 7