|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CDKN4
gptkb:KIP1
gptkb:p27kip1
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
prostate cancer
pituitary adenoma
|
|
gptkbp:discoveredBy
|
gptkb:Polyak_et_al.
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:encodes
|
gptkb:p27^Kip1_protein
|
|
gptkbp:Entrez_Gene_ID
|
1027
ENSG00000111276
|
|
gptkbp:function
|
cell cycle regulation
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:1785
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
CDKN1B
|
|
gptkbp:inhibitedBy
|
gptkb:cyclin-dependent_kinases
|
|
gptkbp:interactsWith
|
gptkb:14-3-3_proteins
gptkb:cyclin_D
gptkb:CDK2
gptkb:CDK4
gptkb:SKP2
gptkb:cyclin_E
|
|
gptkbp:length
|
198 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:lossOfFunctionLeadsTo
|
uncontrolled cell proliferation
|
|
gptkbp:molecularWeight
|
22 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
|
gptkbp:OMIM
|
600778
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1b
|
|
gptkbp:pathway
|
cell cycle
p53 signaling pathway
|
|
gptkbp:postTranslationalModification
|
ubiquitination
acetylation
phosphorylation at Thr187
|
|
gptkbp:product
|
gptkb:p27^Kip1
|
|
gptkbp:regulates
|
gptkb:FOXO3
gptkb:E2F1
gptkb:TGF-beta
phosphorylation
ubiquitination
G1 phase
proteasomal degradation
|
|
gptkbp:significance
|
tumor suppressor
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
P46527
|
|
gptkbp:bfsParent
|
gptkb:p27
gptkb:CDKN1C
|
|
gptkbp:bfsLayer
|
6
|