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gptkbp:instanceOf
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gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:CDKN1B
Cyclin-dependent kinase inhibitor 1B
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|
gptkbp:degradationPathway
|
SCF^Skp2 ubiquitin ligase pathway
|
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gptkbp:discoveredBy
|
gptkb:Polyak_et_al.
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gptkbp:discoveredIn
|
1994
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gptkbp:encodedBy
|
gptkb:CDKN1B_gene
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gptkbp:Entrez_Gene_ID
|
1027
|
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gptkbp:function
|
cell cycle regulation
cyclin-dependent protein serine/threonine kinase inhibitor activity
inhibits cyclin-CDK2 or cyclin-CDK4 complexes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27^Kip1
|
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gptkbp:interactsWith
|
gptkb:cyclin_D
gptkb:CDK2
gptkb:CDK4
gptkb:cyclin_E
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:molecularWeight
|
27 kDa
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Cdkn1b
|
|
gptkbp:PDB
|
1JSU
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
G1 phase of cell cycle
|
|
gptkbp:role
|
tumor suppressor
downregulated in many cancers
|
|
gptkbp:significance
|
prognostic marker in cancer
|
|
gptkbp:UniProtID
|
P46527
|
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gptkbp:bfsParent
|
gptkb:CDKN1B
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gptkbp:bfsLayer
|
7
|