|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:CDKN1B
|
|
gptkbp:associatedWith
|
gptkb:cancer
|
|
gptkbp:biologicalProcess
|
apoptosis
cell migration
cell cycle arrest
|
|
gptkbp:degradedBy
|
gptkb:ubiquitin-proteasome_pathway
SCF^Skp2 complex
|
|
gptkbp:encodedBy
|
gptkb:CDKN1B_gene
|
|
gptkbp:Entrez_Gene_ID
|
1027
|
|
gptkbp:expressionLevelCorrelatesWith
|
prognosis in cancer
|
|
gptkbp:firstDescribed
|
1994
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
cyclin-dependent kinase inhibitor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
p27^Kip1 protein
|
|
gptkbp:inhibitedBy
|
cyclin D-CDK4 complex
cyclin E-CDK2 complex
|
|
gptkbp:interactsWith
|
Skp2
Cks1
cyclin A-CDK2 complex
p21^Cip1 protein
p57^Kip2 protein
|
|
gptkbp:involvedIn
|
tumor suppression
|
|
gptkbp:length
|
198 amino acids
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
gptkb:12p13
|
|
gptkbp:memberOf
|
Cip/Kip family
|
|
gptkbp:mutationAssociatedWith
|
gptkb:multiple_endocrine_neoplasia_type_4
|
|
gptkbp:OMIM
|
600778
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
1JSU
|
|
gptkbp:phosphorylates
|
Thr187
Ser10
Thr198
|
|
gptkbp:positivelyRegulates
|
cell differentiation
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
gptkb:TGF-beta
cell proliferation
cell cycle
G1 phase progression
mitogenic signals
|
|
gptkbp:structure
|
intrinsically disordered protein
|
|
gptkbp:UniProtID
|
P46527
|
|
gptkbp:bfsParent
|
gptkb:CDKN1B
gptkb:CDKN1B_gene
|
|
gptkbp:bfsLayer
|
7
|