|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:BRAF1
gptkb:NS7
gptkb:RAFB1
gptkb:B-RAF
|
|
gptkbp:associatedWith
|
gptkb:LEOPARD_syndrome
gptkb:Cardiofaciocutaneous_syndrome
gptkb:Noonan_syndrome
|
|
gptkbp:biologicalProcess
|
serine/threonine kinase activity
|
|
gptkbp:discoveredBy
|
C. Marshall et al.
|
|
gptkbp:encodes
|
gptkb:B-Raf_protein
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000157764
673
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1993
|
|
gptkbp:function
|
gptkb:protein
|
|
gptkbp:gene
|
gptkb:BRAF
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:1097
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BRAF (human)
|
|
gptkbp:interactsWith
|
gptkb:MEK1
gptkb:MEK2
gptkb:RAS
gptkb:CRAF
gptkb:KSR1
|
|
gptkbp:length
|
766
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
7
|
|
gptkbp:molecularWeight
|
84 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V600K
gptkb:hairy_cell_leukemia
gptkb:cancer
colorectal cancer
melanoma
D594G
G469A
V600E
|
|
gptkbp:OMIM
|
164757
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Braf_(mouse)
|
|
gptkbp:pathway
|
gptkb:MAPK/ERK_pathway
|
|
gptkbp:PDB
|
gptkb:1UWH
4RZV
6U2G
|
|
gptkbp:phosphorylates
|
gptkb:S602
S446
T599
|
|
gptkbp:proteinFamily
|
gptkb:RAF_kinase_family
|
|
gptkbp:regulates
|
cell differentiation
cell survival
cell growth
|
|
gptkbp:subcellularLocation
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:sorafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:BRAF-1
|
|
gptkbp:bfsLayer
|
6
|