Statements (18)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
mutant
|
| gptkbp:aminoAcidChange |
valine to lysine
|
| gptkbp:associatedWith |
gptkb:non-small_cell_lung_cancer
colorectal cancer melanoma |
| gptkbp:codonChange |
GTG to AAG
|
| gptkbp:foundIn |
tumor DNA
|
| https://www.w3.org/2000/01/rdf-schema#label |
V600K
|
| gptkbp:position |
600
|
| gptkbp:regulates |
gptkb:BRAF
|
| gptkbp:result |
constitutive activation of BRAF protein
|
| gptkbp:significance |
oncogenic
|
| gptkbp:target |
gptkb:BRAF_inhibitors
gptkb:MEK_inhibitors |
| gptkbp:typeOfMutation |
missense mutation
|
| gptkbp:bfsParent |
gptkb:BRAF
gptkb:BRAF_gene |
| gptkbp:bfsLayer |
5
|