|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:serine/threonine-protein_kinase_B-raf
gptkb:BRAF
gptkb:proto-oncogene_B-Raf
|
|
gptkbp:associatedWith
|
gptkb:hairy_cell_leukemia
gptkb:cancer
colorectal cancer
melanoma
|
|
gptkbp:discoveredBy
|
gptkb:C._J._Marshall
|
|
gptkbp:encodedBy
|
gptkb:BRAF_gene
|
|
gptkbp:Entrez_Gene_ID
|
673
|
|
gptkbp:enzymeCommissionNumber
|
2.7.11.1
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
serine/threonine-protein kinase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
B-Raf protein
|
|
gptkbp:interactsWith
|
gptkb:MEK1
gptkb:MEK2
gptkb:RAS_protein
gptkb:14-3-3_protein
|
|
gptkbp:involvedIn
|
gptkb:MAPK/ERK_signaling_pathway
|
|
gptkbp:locatedOnChromosome
|
gptkb:7q34
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
~84 kDa
|
|
gptkbp:mutationAssociatedWith
|
V600E
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
gptkb:1UWH
|
|
gptkbp:phosphorylates
|
gptkb:MEK1
gptkb:MEK2
Ser338
Ser446
Ser602
Thr599
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
cell differentiation
cell proliferation
cell survival
|
|
gptkbp:relatedTo
|
gptkb:A-Raf_protein
gptkb:C-Raf_protein
gptkb:Raf_family
|
|
gptkbp:structure
|
kinase domain
regulatory domain
|
|
gptkbp:target
|
gptkb:encorafenib
gptkb:dabrafenib
gptkb:vemurafenib
|
|
gptkbp:UniProtID
|
gptkb:P15056
|
|
gptkbp:bfsParent
|
gptkb:BRAF
gptkb:BRAF_gene
|
|
gptkbp:bfsLayer
|
5
|