Amyloid precursor protein

URI: https://gptkb.org/entity/Amyloid_precursor_protein

GPTKB entity

Statements (81)

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeSplicing	gptkb:APP695 gptkb:APP751 gptkb:APP770
gptkbp:associatedWith	gptkb:Alzheimer's_disease
gptkbp:cleavage	gptkb:beta-secretase gptkb:gamma-secretase
gptkbp:cleavedToForm	gptkb:amyloid_beta
gptkbp:clinicalTrialPhase	Alzheimer's disease therapies
gptkbp:discoveredBy	gptkb:George_Glenner
gptkbp:discoveredIn	1987
gptkbp:domain	intracellular domain transmembrane domain Aβ domain E1 domain E2 domain
gptkbp:encodedBy	gptkb:APP_gene
gptkbp:expressedIn	gptkb:skeletal_muscle gptkb:kidney brain heart
gptkbp:foundIn	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:function	cell surface receptor cell adhesion synapse formation neuronal growth
gptkbp:hasIsoform	gptkb:APP695 gptkb:APP751 gptkb:APP770
gptkbp:hasMouseModel	APP/PS1 mouse APP23 mouse J20 mouse PDAPP mouse Tg2576 mouse
gptkbp:hasPeptideFragment	gptkb:Aβ40 gptkb:Aβ42 APP intracellular domain (AICD) p3 peptide soluble APP alpha (sAPPα) soluble APP beta (sAPPβ)
https://www.w3.org/2000/01/rdf-schema#label	Amyloid precursor protein
gptkbp:interactsWith	gptkb:GSK3β gptkb:tau_protein gptkb:ApoE gptkb:BACE1 gptkb:Fe65 gptkb:nicastrin gptkb:X11 SorLA APPBP1 Presenilin-1 Presenilin-2
gptkbp:locatedOnChromosome	chromosome 21 21q21.3
gptkbp:location	gptkb:endoplasmic_reticulum gptkb:lysosome gptkb:endosome gptkb:Golgi_apparatus gptkb:plasma_membrane
gptkbp:molecularWeight	~110 kDa
gptkbp:mutationAssociatedWith	gptkb:familial_Alzheimer's_disease cerebral amyloid angiopathy
gptkbp:OMIM	104760
gptkbp:orthologIn	gptkb:mouse gptkb:zebrafish gptkb:Drosophila_melanogaster right
gptkbp:PDB	3KTM
gptkbp:postTranslationalModification	palmitoylation phosphorylation glycosylation
gptkbp:signalPeptide	yes
gptkbp:symbol	gptkb:APP
gptkbp:target	therapeutic antibodies gamma-secretase inhibitors BACE inhibitors
gptkbp:UniProtID	gptkb:P05067
gptkbp:bfsParent	gptkb:Amyloid_beta_A4_protein gptkb:P15172
gptkbp:bfsLayer	7