Statements (28)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alsoKnownAs |
BACE
Beta-site APP cleaving enzyme |
| gptkbp:biologicalProcess |
aspartic protease activity
|
| gptkbp:discoveredBy |
1999
|
| gptkbp:EC_number |
3.4.23.46
|
| gptkbp:expressedIn |
gptkb:skeletal_muscle
brain pancreas |
| gptkbp:family |
gptkb:peptidase_A1_family
|
| gptkbp:function |
cleaves amyloid precursor protein (APP)
|
| gptkbp:gene |
gptkb:BACE1
|
| gptkbp:GO |
GO:0004190
|
| https://www.w3.org/2000/01/rdf-schema#label |
beta-secretase
|
| gptkbp:inhibitedBy |
BACE inhibitors
|
| gptkbp:involvedIn |
amyloid-beta peptide generation
|
| gptkbp:involves |
gptkb:Alzheimer's_disease
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_11_(human)
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:orthologIn |
BACE2
|
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:structure |
type I transmembrane protein
|
| gptkbp:substrate |
amyloid precursor protein (APP)
|
| gptkbp:target |
Alzheimer's disease drug development
|
| gptkbp:UniProtID |
P56817
|
| gptkbp:bfsParent |
gptkb:Amyloid_beta_A4_protein
|
| gptkbp:bfsLayer |
7
|