|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:beta-site_APP-cleaving_enzyme_1
gptkb:memapsin-2
|
|
gptkbp:associatedWith
|
amyloid plaques
|
|
gptkbp:biologicalProcess
|
proteolysis
amyloid precursor protein catabolic process
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
integral component of membrane
|
|
gptkbp:cleavage
|
APP at beta-site
|
|
gptkbp:discoveredBy
|
1999
|
|
gptkbp:EC_number
|
3.4.23.46
|
|
gptkbp:encodedBy
|
gptkb:BACE1_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000186318
23621
|
|
gptkbp:enzymeCommissionNumber
|
3.4.23.46
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
pancreas
|
|
gptkbp:fullName
|
gptkb:Beta-secretase_1
|
|
gptkbp:function
|
aspartic endopeptidase activity
beta-secretase activity
|
|
gptkbp:gene
|
gptkb:BACE1
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
933
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
BACE1
|
|
gptkbp:inhibitedBy
|
gptkb:lanabecestat
gptkb:umibecestat
gptkb:verubecestat
|
|
gptkbp:length
|
501 amino acids
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11q23.3
|
|
gptkbp:location
|
gptkb:endosome
gptkb:cell_membrane
gptkb:Golgi_apparatus
|
|
gptkbp:molecularWeight
|
54 kDa
|
|
gptkbp:OMIM
|
605262
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:1FKN
gptkb:4DJY
2ZHV
|
|
gptkbp:postTranslationalModification
|
palmitoylation
phosphorylation
glycosylation
|
|
gptkbp:proteinFamily
|
gptkb:peptidase_A1_family
|
|
gptkbp:RefSeq
|
gptkb:NM_012104
|
|
gptkbp:role
|
gptkb:Alzheimer's_disease
|
|
gptkbp:roleInPathway
|
amyloid-beta formation
|
|
gptkbp:structure
|
type I transmembrane protein
|
|
gptkbp:substrate
|
gptkb:amyloid_precursor_protein
|
|
gptkbp:target
|
Alzheimer's disease drug development
|
|
gptkbp:UniProtID
|
P56817
|
|
gptkbp:bfsParent
|
gptkb:Alzheimer's_disease_pathway
|
|
gptkbp:bfsLayer
|
7
|