|
gptkbp:instanceOf
|
peptide
|
|
gptkbp:accumulatesIn
|
extracellular space
|
|
gptkbp:aggregatesInto
|
fibrils
oligomers
|
|
gptkbp:alsoKnownAs
|
gptkb:Aβ
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
|
|
gptkbp:binds
|
cell membranes
|
|
gptkbp:cause
|
inflammation
oxidative stress
|
|
gptkbp:cleavage
|
gptkb:beta-secretase
gptkb:gamma-secretase
|
|
gptkbp:degradedBy
|
gptkb:neprilysin
gptkb:insulin-degrading_enzyme
|
|
gptkbp:discoveredBy
|
gptkb:George_Glenner
|
|
gptkbp:discoveredIn
|
1984
|
|
gptkbp:encodedBy
|
gptkb:APP_gene
|
|
gptkbp:firstDescribed
|
Alzheimer's disease plaques
|
|
gptkbp:form
|
amyloid plaques
diffuse plaques
neuritic plaques
|
|
gptkbp:foundIn
|
gptkb:human
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
amyloid beta
|
|
gptkbp:inducedBy
|
apoptosis
calcium dysregulation
|
|
gptkbp:influenced
|
tau pathology
|
|
gptkbp:inhibitedBy
|
synaptic function
|
|
gptkbp:interactsWith
|
gptkb:microglia
astrocytes
|
|
gptkbp:involvedIn
|
neurodegeneration
memory impairment
synaptic loss
|
|
gptkbp:involves
|
cerebral amyloid angiopathy
age-related cognitive decline
Down syndrome pathology
|
|
gptkbp:length
|
gptkb:Aβ40
gptkb:Aβ42
|
|
gptkbp:measures
|
cerebrospinal fluid
PET imaging
|
|
gptkbp:molecularWeight
|
~4 kDa
|
|
gptkbp:precursorProtein
|
gptkb:amyloid_precursor_protein
|
|
gptkbp:sequence
|
derived from APP 672–713 (Aβ42)
|
|
gptkbp:structure
|
beta sheet
|
|
gptkbp:studiedIn
|
gptkb:transgenic_mouse_models
|
|
gptkbp:target
|
immunotherapy
monoclonal antibodies
|
|
gptkbp:toxicForm
|
insoluble fibrils
soluble oligomers
|
|
gptkbp:toxicity
|
neurons
|
|
gptkbp:usedIn
|
biomarker research
|
|
gptkbp:bfsParent
|
gptkb:Simoa_technology
gptkb:Single_Molecule_Array_(Simoa)
gptkb:aducanumab
|
|
gptkbp:bfsLayer
|
7
|