|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Amyloid_precursor_protein
AD1
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
Cerebral amyloid angiopathy
|
|
gptkbp:cleavage
|
APP intracellular domain (AICD)
amyloid-beta peptide
|
|
gptkbp:Entrez_Gene_ID
|
ENSP00000350283
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
|
|
gptkbp:function
|
involved in neuronal growth and repair
precursor of amyloid beta peptide
|
|
gptkbp:gene
|
gptkb:APP
|
|
gptkbp:Gene_Ontology_(GO)
|
gptkb:GO:0007268
GO:0005886
GO:0005515
GO:0005634
GO:0007155
GO:0009986
|
|
gptkbp:HGNC_ID
|
620
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P05067
|
|
gptkbp:InterPro
|
IPR002385
IPR022796
|
|
gptkbp:KEGGID
|
hsa:351
|
|
gptkbp:length
|
770
|
|
gptkbp:locatedOnChromosome
|
21
|
|
gptkbp:location
|
21q21.3
|
|
gptkbp:molecularWeight
|
86,753
|
|
gptkbp:OMIM
|
104760
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse App
rat App
zebrafish appa
zebrafish appb
|
|
gptkbp:PDB
|
gptkb:1AAP
2LLM
3UMH
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
proteolytic cleavage
|
|
gptkbp:protein_name
|
gptkb:Amyloid_beta_A4_protein
|
|
gptkbp:proteinFamily
|
PF02177
PF12924
|
|
gptkbp:Reactome
|
R-HSA-977225
|
|
gptkbp:RefSeq
|
NP_000475.1
|
|
gptkbp:subcellularLocation
|
gptkb:endoplasmic_reticulum
gptkb:endosome
gptkb:cell_membrane
gptkb:Golgi_apparatus
secreted
|
|
gptkbp:UniGene
|
gptkb:Hs.654592
|
|
gptkbp:UniProtID
|
gptkb:P05067
|
|
gptkbp:bfsParent
|
gptkb:Amyloid_beta_A4_protein
|
|
gptkbp:bfsLayer
|
7
|