Statements (111)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alternativeSplicing |
yes
|
| gptkbp:associatedWith |
gptkb:Alzheimer's_disease
|
| gptkbp:biologicalProcess |
cell surface receptor
cell adhesion precursor of amyloid beta peptide |
| gptkbp:cleavage |
gptkb:alpha-secretase
gptkb:beta-secretase gptkb:gamma-secretase |
| gptkbp:discoveredBy |
Tanzi et al.
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodes |
gptkb:amyloid_precursor_protein
|
| gptkbp:Entrez_Gene_ID |
351
ENSG00000142192 |
| gptkbp:expressedIn |
gptkb:skeletal_muscle
brain many tissues |
| gptkbp:fullName |
amyloid beta precursor protein
|
| gptkbp:hasIsoform |
gptkb:APP695
gptkb:APP751 gptkb:APP770 |
| gptkbp:HGNC_ID |
HGNC:620
|
| https://www.w3.org/2000/01/rdf-schema#label |
APP gene
|
| gptkbp:length |
770 amino acids (canonical isoform)
|
| gptkbp:locatedOnChromosome |
chromosome 21
|
| gptkbp:mutationAssociatedWith |
gptkb:early-onset_familial_Alzheimer's_disease
|
| gptkbp:OMIM |
104760
|
| gptkbp:orthologInMouse |
gptkb:mobile_application
|
| gptkbp:producesFragment |
gptkb:amyloid_beta_peptide
soluble APP alpha soluble APP beta |
| gptkbp:proteinFamily |
gptkb:zinc-binding_domain
transmembrane domain cytoplasmic domain acidic domain Nuclear localization signal Actin binding region Alpha-helix region Amyloidogenic region Ankyrin binding region Axonal transport signal Aβ domain Beta-sheet region Calmodulin binding region Casein kinase II phosphorylation site Cell adhesion region Cell signaling region Coiled-coil region Cysteine-rich region Cytoskeletal binding region Dimerization domain Disordered region E2 domain ER retention signal Endocytosis signal Endoplasmic reticulum signal peptide Endosomal targeting signal Glycation site Glycogen synthase kinase 3 phosphorylation site Glycosaminoglycan-binding domain Glycosylphosphatidylinositol (GPI) anchor signal Golgi apparatus targeting signal Golgi retention signal GxxxG motif Hydrophilic region Hydrophobic region Kunitz protease inhibitor domain Leucine-rich region Lipid raft targeting sequence Lysine-rich region Lysosomal targeting signal Microtubule binding region Mitochondrial targeting sequence N-linked glycosylation sites NPXY motif Neurite outgrowth-promoting region Neuroprotective region Neurotoxic region Non-amyloidogenic region Nuclear export signal Nuclear matrix targeting signal O-linked glycosylation sites Oligomerization domain Palmitoylation site Plasma membrane targeting signal Proline-rich region Protease recognition site Protein kinase C phosphorylation site Proteolytic cleavage site Serine-rich region Signal-anchor sequence Spectrin binding region Sumoylation site Synaptic vesicle targeting signal Synaptogenic region Threonine-rich region Trans-Golgi network targeting sequence Tubulin binding region Tyrosine kinase phosphorylation site Tyrosine-rich region Ubiquitination site YENPTY motif copper-binding domain growth factor-like domain heparin-binding domain phosphorylation sites signal peptide |
| gptkbp:UniProtID |
gptkb:P05067
|
| gptkbp:bfsParent |
gptkb:Amyloid_beta_A4_protein
gptkb:amyloid_beta_protein |
| gptkbp:bfsLayer |
7
|