ApoE

GPTKB entity

Statements (53)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:ApoE2AssociatedWith decreased Alzheimer's disease risk
gptkbp:ApoE3AssociatedWith neutral Alzheimer's disease risk
gptkbp:ApoE4AssociatedWith increased Alzheimer's disease risk
gptkbp:binds gptkb:heparan_sulfate_proteoglycans
gptkb:LDL_receptor
gptkbp:discoveredBy gptkb:Robert_W._Mahley
gptkbp:discoveredIn 1973
gptkbp:E2Frequency ~8% in Caucasians
gptkbp:E3Frequency ~77% in Caucasians
gptkbp:E4Frequency ~15% in Caucasians
gptkbp:encodedBy gptkb:APOE_gene
gptkbp:expressedIn brain
liver
macrophages
gptkbp:foundIn humans
other mammals
gptkbp:fullName gptkb:Apolipoprotein_E
gptkbp:function cholesterol metabolism
lipid transport
gptkbp:hasIsoform gptkb:ApoE2
gptkb:ApoE3
gptkb:ApoE4
gptkbp:hasPolymorphism gptkb:E4
gptkb:E2
gptkb:E3
gptkbp:HGNC_ID 613
https://www.w3.org/2000/01/rdf-schema#label ApoE
gptkbp:influenced response to dietary fat
response to statins
risk of cardiovascular disease
risk of cognitive decline
gptkbp:involvedIn Alzheimer's disease risk
gptkbp:locatedOnChromosome gptkb:chromosome_19
gptkbp:molecularWeight 34 kDa
gptkbp:mutationAssociatedWith gptkb:type_III_hyperlipoproteinemia
gptkb:dysbetalipoproteinemia
gptkbp:OMIM 107741
gptkbp:PDB gptkb:1LE2
gptkbp:relatedTo gptkb:chylomicrons
gptkb:VLDL
HDL
lipoprotein particles
gptkbp:role gptkb:cardiovascular_disease
atherosclerosis
lipoprotein metabolism
gptkbp:structure 299 amino acids
gptkbp:UniProtID P02649
gptkbp:usedIn genetic testing
biomarker research
gptkbp:bfsParent gptkb:apolipoprotein_E
gptkb:apolipoproteins
gptkbp:bfsLayer 6