gptkbp:instanceOf
|
gptkb:protein
|
gptkbp:ApoE2AssociatedWith
|
decreased Alzheimer's disease risk
|
gptkbp:ApoE3AssociatedWith
|
neutral Alzheimer's disease risk
|
gptkbp:ApoE4AssociatedWith
|
increased Alzheimer's disease risk
|
gptkbp:binds
|
gptkb:heparan_sulfate_proteoglycans
gptkb:LDL_receptor
|
gptkbp:discoveredBy
|
gptkb:Robert_W._Mahley
|
gptkbp:discoveredIn
|
1973
|
gptkbp:E2Frequency
|
~8% in Caucasians
|
gptkbp:E3Frequency
|
~77% in Caucasians
|
gptkbp:E4Frequency
|
~15% in Caucasians
|
gptkbp:encodedBy
|
gptkb:APOE_gene
|
gptkbp:expressedIn
|
brain
liver
macrophages
|
gptkbp:foundIn
|
humans
other mammals
|
gptkbp:fullName
|
gptkb:Apolipoprotein_E
|
gptkbp:function
|
cholesterol metabolism
lipid transport
|
gptkbp:hasIsoform
|
gptkb:ApoE2
gptkb:ApoE3
gptkb:ApoE4
|
gptkbp:hasPolymorphism
|
gptkb:E4
gptkb:E2
gptkb:E3
|
gptkbp:HGNC_ID
|
613
|
https://www.w3.org/2000/01/rdf-schema#label
|
ApoE
|
gptkbp:influenced
|
response to dietary fat
response to statins
risk of cardiovascular disease
risk of cognitive decline
|
gptkbp:involvedIn
|
Alzheimer's disease risk
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
gptkbp:molecularWeight
|
34 kDa
|
gptkbp:mutationAssociatedWith
|
gptkb:type_III_hyperlipoproteinemia
gptkb:dysbetalipoproteinemia
|
gptkbp:OMIM
|
107741
|
gptkbp:PDB
|
gptkb:1LE2
|
gptkbp:relatedTo
|
gptkb:chylomicrons
gptkb:VLDL
HDL
lipoprotein particles
|
gptkbp:role
|
gptkb:cardiovascular_disease
atherosclerosis
lipoprotein metabolism
|
gptkbp:structure
|
299 amino acids
|
gptkbp:UniProtID
|
P02649
|
gptkbp:usedIn
|
genetic testing
biomarker research
|
gptkbp:bfsParent
|
gptkb:apolipoprotein_E
gptkb:apolipoproteins
|
gptkbp:bfsLayer
|
6
|