Statements (96)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:catalyzes |
transfer of ubiquitin to substrate proteins
|
| gptkbp:dysregulationAssociatedWith |
gptkb:cancer
neurodegenerative diseases autoimmune diseases |
| gptkbp:example |
gptkb:TRIM21
gptkb:Cbl gptkb:Cdh1 gptkb:NEDD4 gptkb:TRIM37 gptkb:CHIP gptkb:APC/C gptkb:Cdc20 gptkb:MDM2 gptkb:Itch gptkb:BRCA1 gptkb:Parkin gptkb:FBXW7 gptkb:TRIM33 gptkb:TRAF6 gptkb:TRIM24 gptkb:TRIM28 gptkb:VHL gptkb:TRIM19 gptkb:TRIM25 gptkb:XIAP Mule TRIM29 TRIM32 TRIM63 TRIM11 TRIM22 TRIM36 TRIM38 TRIM39 TRIM41 TRIM44 TRIM50 TRIM54 TRIM55 TRIM59 TRIM62 TRIM71 TRIM8 RNF43 SCF complex Smurf1 HRD1 FBXL2 FBXO32 Siah1 TRIM13 TRIM23 TRIM26 TRIM27 TRIM30 TRIM31 TRIM34 TRIM35 TRIM40 TRIM42 TRIM43 TRIM45 TRIM46 TRIM47 TRIM48 TRIM49 TRIM51 TRIM52 TRIM53 TRIM56 TRIM57 TRIM58 TRIM60 TRIM61 TRIM9 Ube3A |
| gptkbp:foundIn |
eukaryotes
|
| gptkbp:function |
catalyze ubiquitination
|
| https://www.w3.org/2000/01/rdf-schema#label |
ubiquitin ligases
|
| gptkbp:involvedIn |
signal transduction
DNA repair cell cycle regulation immune response protein degradation proteasome pathway |
| gptkbp:regulates |
protein localization
protein stability protein activity |
| gptkbp:requires |
gptkb:E1_ubiquitin-activating_enzyme
gptkb:E2_ubiquitin-conjugating_enzyme |
| gptkbp:type |
HECT-type
RBR-type RING-type |
| gptkbp:bfsParent |
gptkb:IBR_domain
|
| gptkbp:bfsLayer |
8
|