|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:associatedWith
|
gptkb:Parkinson's_disease
|
|
gptkbp:discoveredBy
|
gptkb:Ming_Guo
|
|
gptkbp:discoveredIn
|
1998
|
|
gptkbp:domain
|
RING finger domain
Ubiquitin-like domain
|
|
gptkbp:encodedBy
|
gptkb:PARK2_gene
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
brain
heart
|
|
gptkbp:function
|
E3 ubiquitin ligase
ubiquitin-protein transferase activity
|
|
gptkbp:GOProcess
|
mitochondrial quality control
protein ubiquitination
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Parkin
|
|
gptkbp:interactsWith
|
gptkb:alpha-synuclein
gptkb:DJ-1
gptkb:PINK1
ubiquitin
|
|
gptkbp:involvedIn
|
mitophagy
|
|
gptkbp:locatedIn
|
gptkb:cytoplasm
mitochondria
|
|
gptkbp:locatedOnChromosome
|
6q25.2-q27
|
|
gptkbp:molecularWeight
|
52 kDa
|
|
gptkbp:mutationAssociatedWith
|
autosomal recessive juvenile Parkinsonism
|
|
gptkbp:OMIM
|
602544
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:Drosophila_melanogaster
|
|
gptkbp:PDB
|
4K95
|
|
gptkbp:regulates
|
protein degradation
|
|
gptkbp:UniProtID
|
O60260
|
|
gptkbp:bfsParent
|
gptkb:Memphis_metropolitan_area
|
|
gptkbp:bfsLayer
|
5
|