|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alternativeName
|
gptkb:Ro52
gptkb:SS-A
|
|
gptkbp:antigen
|
autoantibodies in SLE
autoantibodies in Sjögren's syndrome
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
gptkb:Sjögren's_syndrome
autoimmune diseases
|
|
gptkbp:biologicalProcess
|
ubiquitin-protein transferase activity
|
|
gptkbp:cellularComponent
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:discoveredBy
|
gptkb:Janet_M._Rowley
|
|
gptkbp:domain
|
RING finger domain
B-box domain
coiled-coil domain
PRY/SPRY domain
|
|
gptkbp:encodedBy
|
gptkb:TRIM21_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000132109
|
|
gptkbp:expressedIn
|
various tissues
immune cells
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
|
|
gptkbp:gene
|
gptkb:TRIM21
gptkb:tripartite_motif_containing_21
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPathwayRole
|
ubiquitin-mediated proteolysis
immune system pathway
|
|
gptkbp:HGNC_ID
|
11312
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRIM21
|
|
gptkbp:interactsWith
|
antibodies
ubiquitin
|
|
gptkbp:length
|
475 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:11p15.5
|
|
gptkbp:memberOf
|
gptkb:TRIM_protein_family
|
|
gptkbp:mutationAssociatedWith
|
autoimmune disorders
|
|
gptkbp:OMIM
|
109092
|
|
gptkbp:orthologIn
|
gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:2YVR
gptkb:4CG6
2IWG
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:regulates
|
innate immune response
antibody-dependent intracellular neutralization
|
|
gptkbp:UniProtID
|
P19474
|
|
gptkbp:bfsParent
|
gptkb:11p15.5
|
|
gptkbp:bfsLayer
|
6
|