|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:KAP1
TIF1β
|
|
gptkbp:associatedWith
|
gptkb:cancer
intellectual disability
immunodeficiency
|
|
gptkbp:discoveredBy
|
Friedman et al.
|
|
gptkbp:discoveredIn
|
1996
|
|
gptkbp:domain
|
gptkb:bromodomain
RING finger domain
B-box domain
coiled-coil domain
PHD finger
|
|
gptkbp:encodedBy
|
TRIM28 gene
|
|
gptkbp:Entrez_Gene_ID
|
10155
ENSG00000132475
|
|
gptkbp:function
|
epigenetic regulation
chromatin remodeling
transcriptional co-repressor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:5172
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TRIM28
|
|
gptkbp:interactsWith
|
gptkb:SETDB1
HP1 proteins
KRAB domain-containing zinc finger proteins
MAGE proteins
|
|
gptkbp:involvedIn
|
embryonic development
gene silencing
stem cell maintenance
DNA damage response
tumorigenesis
heterochromatin formation
|
|
gptkbp:length
|
835
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_19
|
|
gptkbp:molecularWeight
|
89 kDa
|
|
gptkbp:OMIM
|
601742
|
|
gptkbp:orthologInMouse
|
Trim28
|
|
gptkbp:orthologInZebrafish
|
trim28a
|
|
gptkbp:postTranslationalModification
|
phosphorylation
SUMOylation
|
|
gptkbp:regulates
|
transposable elements
pluripotency genes
imprinted genes
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
chromatin
|
|
gptkbp:UniProtID
|
Q13263
|
|
gptkbp:bfsParent
|
gptkb:TRIM_protein_family
gptkb:Tripartite_motif-containing_protein
gptkb:SETDB1
gptkb:TRIM24
|
|
gptkbp:bfsLayer
|
7
|