|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CDC4
AGO
FBW7
SEL10
hSel-10
|
|
gptkbp:alternativeName
|
F-box and WD repeat domain-containing protein 7
SEL-10 homolog
hCDC4
|
|
gptkbp:discoveredBy
|
researchers studying cell cycle regulation
|
|
gptkbp:encodes
|
F-box/WD repeat-containing protein 7
|
|
gptkbp:Entrez_Gene_ID
|
55294
ENSG00000109670
|
|
gptkbp:expressedIn
|
various human tissues
|
|
gptkbp:firstDescribed
|
early 2000s
|
|
gptkbp:function
|
tumor suppressor
E3 ubiquitin-protein ligase substrate recognition component
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:16712
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
FBXW7
|
|
gptkbp:involvedIn
|
cell cycle regulation
protein degradation
ubiquitin-mediated proteolysis
|
|
gptkbp:locatedOnChromosome
|
gptkb:chromosome_4
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cancer
gptkb:endometrial_cancer
gptkb:T-cell_acute_lymphoblastic_leukemia
colorectal cancer
cholangiocarcinoma
|
|
gptkbp:OMIM
|
606278
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
gptkb:ubiquitin-proteasome_pathway
gptkb:Notch_signaling_pathway
cell cycle pathway
|
|
gptkbp:proteinFamily
|
F-box domain
WD repeat domain
F-box protein family
|
|
gptkbp:regulates
|
gptkb:c-Jun
gptkb:KLF5
gptkb:c-Myc
gptkb:Jun
gptkb:mTOR
gptkb:Notch
gptkb:Mcl-1
gptkb:cyclin_E
SREBP
Aurora-A
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q969H0
|
|
gptkbp:bfsParent
|
gptkb:HGNC:8583
gptkb:NOTCH1
|
|
gptkbp:bfsLayer
|
7
|