|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:C-CBL
gptkb:RNF55
proto-oncogene c-Cbl
|
|
gptkbp:associatedWith
|
gptkb:juvenile_myelomonocytic_leukemia
gptkb:Noonan_syndrome-like_disorder
gptkb:acute_myeloid_leukemia
leukemia
myelodysplastic syndromes
|
|
gptkbp:discoveredBy
|
gptkb:Hidesaburo_Hanafusa
|
|
gptkbp:Entrez_Gene_ID
|
867
ENSG00000110395
|
|
gptkbp:fullName
|
Casitas B-lineage lymphoma proto-oncogene
|
|
gptkbp:function
|
gptkb:E3_ubiquitin-protein_ligase
negative regulator of tyrosine kinase signaling
|
|
gptkbp:gene
|
gptkb:CBL
|
|
gptkbp:HGNC_ID
|
1541
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cbl
|
|
gptkbp:interactsWith
|
gptkb:EGFR
gptkb:Src
gptkb:c-Met
gptkb:Grb2
|
|
gptkbp:locatedOnChromosome
|
11q23.3
|
|
gptkbp:location
|
gptkb:cytoplasm
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:mutationAssociatedWith
|
deletion
insertion
missense
oncogenic transformation
|
|
gptkbp:OMIM
|
165360
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:pathway
|
gptkb:EGFR_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
ubiquitin-mediated proteolysis
|
|
gptkbp:phosphorylates
|
tyrosine 700
tyrosine 731
tyrosine 774
|
|
gptkbp:postTranslationalModification
|
phosphorylation
sumoylation
ubiquitination
|
|
gptkbp:proteinFamily
|
SH2 domain
RING finger domain
proline-rich region
|
|
gptkbp:regulates
|
gptkb:receptor_tyrosine_kinases
cell signaling
protein degradation
|
|
gptkbp:UniProtID
|
P22681
|
|
gptkbp:bfsParent
|
gptkb:CBL_gene
gptkb:Chrysoberyl
|
|
gptkbp:bfsLayer
|
7
|