|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:E-cadherin
|
|
gptkbp:associatedWith
|
gptkb:cancer
gastric cancer
|
|
gptkbp:clinicalTrialPhase
|
genetic testing for CDH1 mutations
|
|
gptkbp:component
|
adherens junction
|
|
gptkbp:decreasedExpressionAssociatedWith
|
cancer progression
|
|
gptkbp:discoveredBy
|
gptkb:Masatoshi_Takeichi
|
|
gptkbp:discoveredIn
|
1977
|
|
gptkbp:domain
|
cytoplasmic domain
extracellular cadherin repeats
|
|
gptkbp:encodedBy
|
gptkb:CDH1_gene
|
|
gptkbp:Entrez_Gene_ID
|
999
ENSG00000039068
|
|
gptkbp:expressedIn
|
epithelial tissues
|
|
gptkbp:fullName
|
Cadherin-1
|
|
gptkbp:function
|
tumor suppression
calcium ion binding
cell-cell adhesion
|
|
gptkbp:gene
|
gptkb:CDH1
|
|
gptkbp:GOProcess
|
cell adhesion
|
|
gptkbp:HGNC_ID
|
1748
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Cdh1
|
|
gptkbp:interactsWith
|
gptkb:alpha-catenin
gptkb:p120-catenin
gptkb:beta-catenin
|
|
gptkbp:locatedOnChromosome
|
16q22.1
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
120 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:hereditary_diffuse_gastric_cancer
gptkb:lobular_breast_cancer
|
|
gptkbp:OMIM
|
192090
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Drosophila_melanogaster
|
|
gptkbp:pathway
|
gptkb:Wnt_signaling_pathway
cell adhesion molecules pathway
|
|
gptkbp:PDB
|
2O72
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
transcription factors
epigenetic modifications
|
|
gptkbp:role
|
cell signaling
epithelial-mesenchymal transition
cancer metastasis
tissue morphogenesis
|
|
gptkbp:structure
|
transmembrane protein
|
|
gptkbp:targetOfDrug
|
gptkb:cancer
|
|
gptkbp:UniProtID
|
P12830
|
|
gptkbp:bfsParent
|
gptkb:chromosome_7_(mouse)
gptkb:CDH1
gptkb:CDH1_gene
|
|
gptkbp:bfsLayer
|
7
|