tyrosine-protein kinase TYK2

URI: https://gptkb.org/entity/tyrosine-protein_kinase_TYK2
GPTKB entity
Statements (48)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:JAK2
gptkb:Janus_kinase_2
JAK tyrosine kinase 2
gptkbp:associatedWith gptkb:systemic_lupus_erythematosus
gptkb:immunodeficiency_35
autoimmune diseases
psoriasis
gptkbp:enzymeCommissionNumber 2.7.10.2
gptkbp:expressedIn gptkb:leukocytes
immune cells
gptkbp:function signal transduction
non-receptor tyrosine kinase
gptkbp:gene gptkb:TYK2
gptkbp:HGNC_ID HGNC:12440
https://www.w3.org/2000/01/rdf-schema#label tyrosine-protein kinase TYK2
gptkbp:interactsWith gptkb:JAK1
gptkb:STAT_proteins
gptkb:IFNAR1
interleukin receptors
gptkbp:involves gptkb:JAK-STAT_signaling_pathway
gptkbp:length 1187
gptkbp:locatedOnChromosome gptkb:chromosome_19p13.2
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:member gptkb:Janus_kinase_family
gptkbp:molecularWeight 134 kDa
gptkbp:mutationAssociatedWith increased susceptibility to infection
altered cytokine signaling
gptkbp:OMIM 176941
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologInMouse gptkb:Tyk2
gptkbp:PDB 4OLI
gptkbp:phosphorylates gptkb:STAT1
gptkb:STAT2
gptkb:STAT4
gptkb:STAT6
gptkb:STAT3
gptkb:STAT5
gptkbp:postTranslationalModification phosphorylation
gptkbp:RefSeq NP_003322.4
gptkbp:targetOfDrug gptkb:tofacitinib
gptkb:baricitinib
gptkb:BMS-986165
gptkb:deucravacitinib
gptkbp:UniProtID P29597
gptkbp:bfsParent gptkb:TYK2
gptkbp:bfsLayer 8