tyrosine-protein kinase TYK2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:alternativeName	gptkb:JAK2 gptkb:Janus_kinase_2 JAK tyrosine kinase 2
gptkbp:associatedWith	gptkb:systemic_lupus_erythematosus gptkb:immunodeficiency_35 autoimmune diseases psoriasis
gptkbp:enzymeCommissionNumber	2.7.10.2
gptkbp:expressedIn	gptkb:leukocytes immune cells
gptkbp:function	signal transduction non-receptor tyrosine kinase
gptkbp:gene	gptkb:TYK2
gptkbp:HGNC_ID	HGNC:12440
gptkbp:interactsWith	gptkb:JAK1 gptkb:STAT_proteins gptkb:IFNAR1 interleukin receptors
gptkbp:involves	gptkb:JAK-STAT_signaling_pathway
gptkbp:length	1187
gptkbp:locatedOnChromosome	gptkb:chromosome_19p13.2
gptkbp:location	gptkb:nucleus gptkb:cytoplasm
gptkbp:member	gptkb:Janus_kinase_family
gptkbp:molecularWeight	134 kDa
gptkbp:mutationAssociatedWith	increased susceptibility to infection altered cytokine signaling
gptkbp:OMIM	176941
gptkbp:organism	gptkb:Homo_sapiens
gptkbp:orthologInMouse	gptkb:Tyk2
gptkbp:PDB	4OLI
gptkbp:phosphorylates	gptkb:STAT1 gptkb:STAT2 gptkb:STAT4 gptkb:STAT6 gptkb:STAT3 gptkb:STAT5
gptkbp:postTranslationalModification	phosphorylation
gptkbp:RefSeq	NP_003322.4
gptkbp:targetOfDrug	gptkb:tofacitinib gptkb:baricitinib gptkb:BMS-986165 gptkb:deucravacitinib
gptkbp:UniProtID	P29597
gptkbp:bfsParent	gptkb:TYK2
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	tyrosine-protein kinase TYK2