|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alternativeName
|
gptkb:JAK2
Janus kinase family member 2
tyrosine-protein kinase JAK2
|
|
gptkbp:associatedWith
|
gptkb:polycythemia_vera
essential thrombocythemia
primary myelofibrosis
|
|
gptkbp:discoveredBy
|
1992
|
|
gptkbp:EC_number
|
2.7.10.2
|
|
gptkbp:encodedBy
|
gptkb:JAK2_gene
|
|
gptkbp:Entrez_Gene_ID
|
ENSG00000096968
GC09M050774
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:function
|
signal transduction
tyrosine kinase activity
|
|
gptkbp:gene
|
gptkb:JAK2
|
|
gptkbp:HGNC_ID
|
6192
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Janus kinase 2
|
|
gptkbp:involves
|
gptkb:JAK-STAT_signaling_pathway
|
|
gptkbp:locatedIn
|
gptkb:chromosome_9
|
|
gptkbp:member
|
gptkb:Janus_kinase_family
|
|
gptkbp:molecularWeight
|
~130 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:V617F
|
|
gptkbp:OMIM
|
147796
|
|
gptkbp:orthologInMouse
|
Jak2
|
|
gptkbp:PDB
|
gptkb:4BBE
|
|
gptkbp:phosphorylates
|
gptkb:STAT_proteins
|
|
gptkbp:targetOfDrug
|
gptkb:fedratinib
gptkb:ruxolitinib
|
|
gptkbp:UniProtID
|
O60674
|
|
gptkbp:bfsParent
|
gptkb:JAK2
|
|
gptkbp:bfsLayer
|
7
|